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Organic Functionalization of Fullerenes

Water soluble Fullerene Derivatives exhibit a number of exciting biological activities that attracted attention of many research groups around the world. Intensive studies resulted in the discovering antiviral, antitumor, antimicrobacterial and antioxigenyc effects of the C60 derivatives.

As a result, the new series of AminoAcids and Peptide Derivatives of C60 possessing well pronounced membranotropic, antioxidant,antiviral and immunomodulating properties was designed.

We offer the sodium salt of Aminocapronic acid (1) and Aminobutyric Acid (2) which are very soluble in the water ( >50mg/ml ) and exhibit a strong anti - HIV and adjuvant activity:
  1. C60(H) NH ( CH2 )5 COO Na
  2. C60(H) NH ( CH2 )3 COO Na
Please contact us regarding of the minimum order, price, delivery terms etc.

Also we can offer the Water soluble C60 Derivatives with many another AminoAcids: Gly, Ala, Ser, Pro, Arg etc.


1.“Fullerene-Derivatized Amino Acids:Synthesis,Characterization,
Antioxidant Properties and Solid-Phase Peptide Synthesis”
J.Yang et al., - Chemistry, 2007, 13(9): 2530-2545

2. “ The Use of Fullerene Substituted Phenylalanine Amino Acids as a Passport for Peptides through Cell Membranes “
J.Yang et al., - Org.Biomol.Chem., 2007 Jan. 21, 5(2): 260-266

3. “ Human Immunodeficiency Virus-Reserve Transcriptase Inhibition and Hepatitis C Virus RNA-dependent RNA Polymerase Inhibition Activities of Fullerene Derivatives “
T.Mashino et al., - Bioorg.Med.Chem.Lett. 2005 Feb. 15, 15(4): 1107-1109

4. “ Synthesis and Biological Properties of Fullerene-containing Amino Acids and Peptides “
D.Pantarotto et al., - Mini Rev.Med.Chem., 2004 Sep., 4(7): 805-814

5. “ HIV Reproduction Inhibition by Amino Acid and Dipeptide Derivatives of Fullerene C60 “
G.G.Miler et al., - Antibiot. Khimioter., 2004, 49(12): 3-8

6. “ Enantiomers of the Amino Acid Derivatives of Fullerene C60 possess Stereospecific Membranotropic Properties “
G.N.Bogdanov et al., - Dokl.Biochem.Biophys. 2004 May-June, 396: 165-167

7. “ In Vitro Antiviral Activity of Fullerene Amino Acid Derivatives in Cytomegalovirus Infection “
M.G.Medzhidova et al., - Antibit.Khimioter., 2004, 49(8-9): 13-20

8. “ Suppression of Cytomegalovirus Infection in Cell System by Fullerene Amino Acid Derivatives “
N.E.Fedorova et al., - Vopr.Virusol., 2002 Jan-Feb., 47(1): 30-34

A.Bianco et al., - J.Pept.Sci., 2001 Apr., 7(4): 208-219

Application of MTR’s Fullerenes

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